Professional Profile

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Photo Dept: Pharmaceutical Sciences

Interested in research in autism
B.S.- Pharmacy - North Gujarat University
M.S.-Pharmacology - Northeastern University
Ph.D.- Pharmacology - Northeastern University

Recent Publications

1. Trivedi MS , Deth R. Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention. Front Neurosci. 2015 Jan 22;8:444. PMID: 25657617

2. Milane L, Trivedi M , Singh A, Talekar M, Amiji M. Mitochondrial biology, targets, and drug delivery. J Control Release. 2015 Jun 10;207:40-58. doi: 10.1016/j.jconrel.2015.03.036. Epub 2015 Apr 1. Review. PMID: 25841699

3. Salzano G, Navarro G, Trivedi MS , De Rosa G, Torchilin VP. Multifunctional Polymeric Micelles Co-loaded with Anti-Survivin siRNA and Paclitaxel Overcome Drug Resistance in an Animal Model of Ovarian Cancer.. Mol Cancer Ther. 2015 Apr;14(4):1075-84.MCT-14-0556. Epub 2015 Feb 5. PMID: 25657335

4. Essex S, Navarro G, Sabhachandani P, Chordia A, Trivedi M , Movassaghian S, Torchilin VP. Phospholipid-modified PEI-based nanocarriers for in vivo siRNA therapeutics against multidrug-resistant tumors. Gene Ther. 2015 Mar;22(3):41-50. Epub 2014 Oct 30. PMID: 25354685

5. Trivedi M , Shah J, Hodgson N, Byun HM, Deth R. Morphine induces redox-based changes in global DNA methylation and retrotransposon transcription by inhibition of excitatory amino acid transporter type 3-mediated cysteine uptake. Mol Pharmacol. 85(5):747-57 (2014).

6. Trivedi MS , Shah JS, Al-Mughairy S, Hodgson NW, Simms B, Trooskens GA, Van Criekinge W, Deth RC. Food-derived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences. J Nutr Biochem. 25(10):1011-8 (2014).

7. Hodgson N,Trivedi M , Muratore C, Li S, Deth R. Soluble oligomers of amyloid-? cause changes in redox state, DNA methylation, and gene transcription by inhibiting EAAT3 mediated cysteine uptake. J Alzheimers Dis. 2013;36(1):197-209. PMID: 23579332

8. Muratore CR, Hodgson NW, Trivedi MS, Abdolmaleky HM, Persico AM, Lintas C, De la Monte S, Deth RC. Age-dependent decrease and alternative splicing of methionine synthase mRNA in human cerebral cortex and an accelerated decrease in autism. PLoS One. 2013;8(2):e56927. Epub 2013 Feb 20. PMID: 23437274

9. Movassaghian S, Moghimi HR, Shirazi FH, Koshkaryev A, Trivedi MS , Torchilin VP.Efficient down-regulation of PKC-? gene expression in A549 lung cancer cells mediated by antisense oligodeoxynucleotides in dendrosomes. Int J Pharm. 2013 Jan 30;441(1-2):82-91. Epub 2012 Dec 20. PMID: 23262426

10. Waly MI, Hornig M, Trivedi M , Hodgson N, Kini R, Ohta A, Deth R. Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism. Autism Res Treat. 2012;2012:190930. Epub 2012 Jun 19. PMID: 22934169

11. Trivedi MS , Deth RC. Role of a redox-based methylation switch in mRNA life cycle (pre- and post-transcriptional maturation) and protein turnover: implications in neurological disorders. Front Neurosci. 2012 Jun 26;6:92.. eCollection 2012. PMID: 22740813

Professional Associations

Member: Society for Neuroscience; President for the Boston Area Neuroscience Chapter (2012-14)
Member: American Association of Pharmaceutical sciences (AAPS), Secretary for the Northeastern chapter (2011-12) Member:American Association of Colleges of Pharmacy (AACP)
Research Interests:
Epigenetic and transcriptional changes in
Neurodevelopmental disorders - Autism
Drug-Addiciton and withdrawal
Neurodegenerative diseases - Azlheimer's and Parkinson's
Tumor Biology and microenvironment
Research Interests keywords:

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