Professional Profile

Enrique A. Nieves, B.S, M.S, Ph.D

Photo Clinical Assistant Professor
Dept: Pharmaceutical Sciences
Phone: 787-773-6571
Campus: Puerto Rico

As former Director of R&D in the pharmaceutical industry, Dr E. Nieves led the development of many drugs available in the U.S market today. He has been a key participant in the technology transfer and NDA filling processes of new drugs. He is an active chemist and pharmacist, and a member of various professional chemical and pharmaceutical organizations. He initiated research in nanosystems at the College of Pharmacy at Nova Southeastern University which has produced some patents in three years and has stimulated student research in this field. Dr. Nievesā€˜s research interests include the application of nanotechnology in the development of novel molecular carrier systems and new drug design. He developed a linear miniaturization method for efficient technology transfer which he currently uses in drug development.
Research Interests keywords:
Stabilization of peptides and protein drugs, drug delivery of large molecules, drug-dendrimer interactions, clinical pharmaceutics applied to metabolic diseases.
Students at the Puerto Rico site who take the course PHA5999 coordinated by Dr M. Clark in Davie will gain hands on experience in drug discovery and development in the R&D Laboratory managed by Dr. E. Nieves. The students will work in different phases of the new product process. These include the following studies: drug characterization, drug-excipient compatibility, binary studies, stability studies, pre-formulation, dosage form design, and evaluation. Analytical techiques used in pharmacy include Differential Scanning Calorimetry for the characterization of polymorphic forms of drugs, dissolution profile studies for tablets, capsules, powders, semisolids matrixes, and transdermal polymers; HPLC indicating assays for the measurement of impurities of APIs and determination of drug shelf life; equilibrium dialysis for complexation studies including drug-protein binding studies; drug-polymer interactions and drug-ligand affinity studies; evaporation techniques to concentrate drugs in suspension and solution; freeze drying, particle size measurements, physical characterizations of tablets, tablet formation, and nanotechnology techniques applied to drugs. Circular Dichroism and Optical Rotatory Dispersion for the structure of proteins and protein-drug complexes are also available. Specific phases of a large project may be assigned to the student once proficiency is gained in the analytical techniques required. Some of the work may be performed in outside laboratories to use technologies not available at the NSU Lab. For information the student should contact Dr. Blanca Ortiz, Dr. Enrique Nieves, or Dr. Michelle Clark.
Contact information: Dr. Blanca Ortiz,
Dr. Enrique Nieves,
Dr. Michelle Clark,
Date Posted: 08/19/2014

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